I just downloaded the last stable Zelda version (2.50.2).
I'm at Win 10 Pro x64 (v. 10.0.16299.214).

Romview autocrashes and Zelda can't run properly at full-screen mode.
It flickers so you can't use it.
At windowed mode runs properly, although it displays a small windows that can't be maximized or get bigger.
Altering resolution, doesn't seems to have any effect.

The rest of EXEs seems to run properly.